Performance & Recovery Science

Your performance depends
on the quality of your recovery.

Every training session creates the stimulus for adaptation — but it also creates physiological demands your body must respond to between sessions.

Discover why molecular hydrogen has become an active area of scientific research in exercise recovery, oxidative stress and human performance.

Performance isn't built during training.

Training provides the stimulus. The real physiological changes happen afterwards, as your body recovers, adapts and prepares for the next session.

01 — Performance & Adaptation

Every training session creates two responses.

The first is the stimulus for adaptation — the mechanical and metabolic load that, given adequate recovery, drives the body to get fitter, stronger or faster over time.

The second is a physiological cost. Muscular contractions increase the production of reactive oxygen species (ROS). At higher levels, these can contribute to exercise-induced oxidative stress — but ROS are not simply damaging by-products to be minimised. They also participate in redox-sensitive cellular signalling involved in skeletal-muscle remodelling and adaptation to training.7–9

Recovery is where these processes continue to unfold — restoring physiological function, repairing and remodelling tissue where required, and supporting the cellular processes through which repeated training can produce adaptation.10

Diagram: training leads to recovery, which leads to adaptation, which produces performance; cellular and redox signalling interacts with recovery and adaptation. TRAINING Creates the stimulus RECOVERY Repair & regulation ADAPTATION Physiological response PERFORMANCE The outcome CELLULAR / REDOX SIGNALLING Interacts with, rather than opposes, recovery and adaptation.

02 — Cellular Physiology

Oxidative stress is not simply the enemy.

Reactive oxygen species (ROS) are continually generated through normal cellular metabolism and play roles in processes including cellular signalling and immune function. During muscular contraction, ROS production increases through several cellular pathways.7,9,11

That activity is not simply damage to be minimised. At physiological levels, ROS act as signalling molecules, activating redox-sensitive pathways involved in processes such as mitochondrial biogenesis, antioxidant defence and skeletal-muscle remodelling. These signals form part of the complex biological response through which repeated exercise produces adaptation.7,11,12

The concern arises when oxidant production and antioxidant/redox-regulatory systems become sufficiently imbalanced that physiological signalling shifts towards oxidative distress and cellular damage. The body continuously regulates this dynamic redox environment — a state commonly described as redox homeostasis.13,14

Diagram: training stress leads to cellular and redox signals, which fork into two outcomes — an adaptive response when balanced and well-recovered, or excess, poorly managed load when under-recovered and chronic. TRAINING STRESS CELLULAR / REDOX SIGNALS ADAPTIVE RESPONSE balanced, well-recovered EXCESS / POORLY MANAGED LOAD under-recovered, chronic

TRAINING STRESS

CELLULAR /
REDOX SIGNALS

ADAPTIVE RESPONSE

balanced, well-recovered

EXCESS / POORLY MANAGED LOAD

under-recovered, chronic

Both pathways share the same underlying signalling activity — the outcome depends on load relative to recovery capacity.

Diagram: molecular hydrogen, two hydrogen atoms bonded together, with molecular mass, kinetic diameter and a note on membrane diffusibility. H H H₂ — MOLECULAR HYDROGEN Two hydrogen atoms bonded together Molecular mass: 2.016 g/mol Kinetic diameter: ~0.29 nm19 Its small size and non-polar nature allow H₂ to diffuse rapidly across biological membranes.1

03 — Molecular Hydrogen

So where does molecular hydrogen fit?

Molecular hydrogen — H₂ — is two hydrogen atoms bonded together: the smallest diatomic molecule. It is not synonymous with alkaline water. Alkalinity describes pH; hydrogen-rich water contains dissolved molecular hydrogen gas. Electrolysis can produce alkaline water and dissolved H₂ simultaneously, but research on electrolyzed-reduced water distinguishes the dissolved H₂ from alkalinity itself.15

Because H₂ is a small, non-polar gas, it can diffuse rapidly across biological membranes and into tissues and cellular compartments. This unusual diffusibility is one reason researchers have investigated its potential biological effects.1,16

A landmark 2007 study proposed that H₂ could act as a selective antioxidant, interacting with highly reactive free radicals while leaving other reactive species involved in normal cell signalling comparatively unaffected.1 That finding helped establish the modern field of molecular-hydrogen research. Since then, research has suggested that H₂'s biological effects may extend beyond direct antioxidant activity, potentially involving the body's own redox regulation, cellular signalling and gene expression.17,18 The precise mechanisms are still being investigated.

04 — Research Interest

Why H₂ has drawn scientific attention.

01

Small

H₂ has a molecular mass of just 2.016 g/mol and a kinetic diameter of approximately 0.29 nm. Its small size is one of the physical properties underlying its high diffusibility.19

02

Diffusible

As a small, non-polar gas, H₂ can diffuse across biological membranes and distribute into cells and tissues. Experimental research has also investigated its distribution into intracellular compartments, including mitochondria.1,16

03

Redox Signalling

Early research focused on H₂'s interactions with highly reactive oxidants. More recent research has broadened that picture, investigating how H₂ may also influence the body's own redox regulation, cellular signalling and adaptive defence responses. The mechanisms responsible for these effects remain an active area of investigation.1,17,18

04

Rapid

In human studies, H₂ from hydrogen-rich water has been detected in exhaled breath within minutes of ingestion, with peak breath concentrations reported at approximately 10–15 minutes — demonstrating rapid absorption and systemic distribution.20,21

From the science, back to the athlete

05 — Athletic Research

What does the research say about athletes?

From mechanism to performance.

Human studies have now tested molecular hydrogen across endurance exercise, resistance training, repeated efforts and recovery — examining outcomes ranging from power output and perceived exertion to blood lactate and muscle function.

Across 27 publications involving 597 participants, a 2024 systematic review and meta-analysis found significant pooled effects for lower-limb explosive power, perceived exertion and blood lactate — outcomes directly relevant to how athletes perform and experience demanding exercise.22

Where the evidence is more mixed

Effects were not significant across every performance measure, including VO₂max, aerobic endurance, anaerobic endurance and muscular strength, suggesting that any effects of molecular hydrogen may depend on the outcome and exercise context being measured.22

A related 2023 systematic review and meta-analysis — 17 publications, 19 studies, 402 participants — similarly found significant pooled reductions in perceived exertion and blood lactate, describing the evidence for an effect on exercise-related fatigue as moderate.29

Hydrogen-rich water, blood lactate and muscle function

Population
10 male elite soccer players.
What was measured
Blood lactate, peak torque and muscle activity following cycling at 75% VO₂max followed by 100 maximal isokinetic knee extensions, comparing hydrogen-rich water against a placebo.
What researchers reported
Blood lactate increased after exercise in the placebo condition but not in the hydrogen-water condition. Peak torque declined significantly during repeated knee extension with placebo, while the early decline was attenuated with hydrogen-rich water. The same study found no significant difference between conditions in oxidative-injury markers or creatine kinase.2
Context & limitation
This was a small pilot study involving only 10 elite male soccer players. The authors called for larger studies, and the findings should not be generalised across sports or populations.
View Study

Hydrogen-rich water, resistance training and recovery

Population
18 resistance-trained men, mean age approximately 20 years.
What was measured
Muscular endurance, total power output, neuromuscular function and subjective recovery responses during resistance exercise and across the subsequent recovery period, comparing hydrogen-rich water against a placebo in a randomized, double-blind, crossover design.
What researchers reported
Hydrogen-rich water produced 9.6% greater total power output (p=0.032) and 11.2% more repetitions completed (p=0.019) than placebo across the resistance-training sets.3 Countermovement jump, muscle soreness and subjective recovery ratings did not differ significantly between conditions.
Context & limitation
A controlled, double-blind, crossover study showing a clear in-session performance signal in resistance-trained men. The sample was small and specific to young trained males, so whether the same response holds across other populations, sports or longer training blocks remains untested.
View Study

Hydrogen-rich water and redox responses to repeated exercise

Population
8 physically active men.
What was measured
Muscle performance and blood markers associated with oxidative stress across three consecutive days of strenuous exercise, comparing hydrogen-rich water against a placebo in a randomized crossover design.
What researchers reported
Hydrogen-rich water suppressed the exercise-associated reduction in blood total antioxidant capacity compared with placebo. The study also assessed countermovement jump, maximal voluntary knee-extensor contraction and repeated sprint cycling; none of these performance measures differed significantly between hydrogen-rich water and placebo.4
Context & limitation
This was a very small randomized crossover trial. Changes in circulating redox biomarkers do not necessarily translate into improved recovery or athletic performance, so these findings should be interpreted as physiological rather than direct performance evidence.
View Study

Hydrogen-rich water, muscle damage and recovery markers in elite athletes

Population
22 female elite athletes participating in handball and skeleton sports.
What was measured
Body composition, maximal isokinetic torque, biochemical markers of muscle damage and antioxidant status — including creatine kinase, vitamin E and interleukin-10 — and perceived stress and recovery via the Recovery-Stress Questionnaire for Athletes, in a randomized, double-blind, placebo-controlled trial of hydrogen-rich water tablets.
What researchers reported
The hydrogen-rich water group differed from placebo on maximal torque and on several biochemical measures, including lower creatine kinase and higher vitamin E and interleukin-10. The Recovery-Stress Questionnaire-Sport did not show a significant effect on perceived stress or recovery rates — the strength and biochemical findings did not extend to self-reported recovery.23
Context & limitation
A small trial in two specific elite sports; findings in this narrow population should not be generalised beyond it. Several authors disclose commercial involvement in the molecular-hydrogen industry, noted here as relevant context for interpreting the results.
View Study

Hydrogen-rich water and recovery between same-day sessions

Population
12 elite fin swimmers (8 women, 4 men).
What was measured
Creatine kinase, muscle soreness and countermovement jump height following two strenuous sessions on the same day — a morning set of 12 × 50m sprints and an afternoon 400m time trial — comparing hydrogen-rich water against a placebo in a randomized, double-blind, crossover design.
What researchers reported
Twelve hours after the second session, creatine kinase was lower (156 vs 190 U/L, p=0.043), muscle soreness was lower (34mm vs 42mm on a visual analogue scale, p=0.045), and countermovement jump height was greater (30.7cm vs 29.8cm, p=0.014) with hydrogen-rich water than placebo.30 These differences were not significant at every timepoint measured across the day.
Context & limitation
A small crossover trial of 12 elite swimmers; the per-subject dose was fixed rather than adjusted for body mass, and the study did not examine the mechanisms behind these differences. It adds a same-day, repeated-session recovery picture that the other studies here do not directly test.
View Study

06 — Broader Context

Research beyond athletics.

The scientific interest in molecular hydrogen extends beyond exercise physiology, with research spanning redox biology, inflammatory signalling, mitochondrial function, cognition and ageing. The maturity of the evidence varies considerably between these areas.

  • Oxidative Stress

    Mechanistic + human research

    Molecular hydrogen's relationship with redox biology is one of its most extensively researched areas. A 2024 systematic review and meta-analysis found significantly greater biological antioxidant potential following H₂ supplementation in healthy adults, with a larger effect during intermittent exercise. The same analysis did not find significant changes across every oxidative-stress marker measured.31

  • Inflammatory Signalling

    Predominantly experimental/mechanistic

    Inflammatory signalling is another major area of molecular-hydrogen research. Experimental studies have reported effects involving pathways such as NF-κB and inflammatory cytokine signalling, contributing to interest in how H₂ may interact with the body's regulation of inflammatory responses. Much of this mechanistic evidence remains preclinical, and translation to consistent human outcomes is still being investigated.17,24

  • Mitochondrial & Cellular Research

    Predominantly mechanistic/preclinical

    Mitochondria have emerged as an important focus in molecular-hydrogen research, with studies exploring relationships between H₂, mitochondrial redox regulation, cellular signalling and mitochondrial function. This has led researchers to investigate mitochondria as one possible hub through which H₂'s broader biological effects may be mediated. The precise pathways remain an active area of investigation.25

  • Cognitive Research

    Human trial + experimental research

    Molecular hydrogen and hydrogen-containing reduced water have been investigated in human cognitive research. In a 2024 double-blind randomized trial in healthy older adults, six months of natural reduced water was associated with significant improvements in measures of attention and short-term memory compared with tap water.28 Earlier research in people with mild cognitive impairment also reported improvements in cognitive scores within a prespecified APOE4 subgroup following hydrogen-rich water, although the full study population did not show a significant difference.26

  • Ageing-Related Research

    Early human research

    Human research has also begun exploring molecular hydrogen in healthy ageing. In a six-month randomized controlled pilot trial involving 40 adults aged 70 and over, hydrogen-rich water was associated with favourable changes in several ageing-related measures, including telomere length, TET2 expression and selected brain metabolites, alongside improved chair-stand performance compared with control water.27 The study was small and exploratory, but its findings have helped support further interest in H₂ and healthy-ageing research.

None of this indicates that molecular hydrogen treats, prevents or cures any condition. It indicates only that H₂ is being examined, as a molecule, across several distinct fields of research — of which exercise physiology and athletic recovery, the focus of this page, is one.

07 — FAQs

Questions athletes ask first.

What is molecular hydrogen?
Molecular hydrogen (H₂) is simply two hydrogen atoms bonded together — a very small, non-polar gas molecule. H₂ is also produced naturally within the human gut as microorganisms ferment dietary carbohydrates.32
Is hydrogen water the same as alkaline water?
No. Hydrogen-rich water contains dissolved molecular hydrogen (H₂), while alkalinity describes the water's pH. Some electrolysis systems produce alkaline water and dissolved H₂ at the same time, but the two properties are not interchangeable. Research into electrolyzed-reduced water increasingly identifies dissolved H₂ — rather than alkaline pH itself — as the biologically relevant component being investigated.15
Why are athletes interested in molecular hydrogen?
Because human exercise studies are beginning to report interesting effects across outcomes relevant to athletes — including perceived exertion, blood lactate, explosive power and muscular endurance. Systematic reviews and controlled trials suggest that the response is not identical across every type of exercise or performance measure, but the emerging evidence has made H₂ an active area of sports-performance and recovery research.3,22,29
Is oxidative stress always bad?
No. Reactive oxygen species produced during exercise are not simply damaging by-products — at physiological levels they also participate in cellular signalling involved in training adaptation.7,11 The issue is balance: oxidative stress occurs when oxidant activity sufficiently exceeds the body's redox-regulatory capacity, potentially shifting useful signalling towards cellular damage.13
How is molecular hydrogen being studied in exercise and recovery?
Researchers have tested H₂ across endurance exercise, resistance training, repeated high-intensity efforts and recovery protocols. Human studies have measured outcomes including blood lactate, perceived exertion, power output, muscular endurance, muscle function and redox biomarkers. Meta-analyses now allow some of these findings to be examined across multiple studies rather than relying only on individual trials.3,22,29 See Athletic Research above for examples of the human evidence.
How long does molecular hydrogen remain dissolved in water?
H₂ is a dissolved gas, so once hydrogen-rich water is exposed to air it gradually escapes into the atmosphere. How quickly this happens depends on factors including the starting H₂ concentration, temperature, container material, headspace and how well the container is sealed. For that reason, freshly produced or newly opened hydrogen-rich water is generally best consumed relatively soon rather than left exposed to air for extended periods.33
Where can I read the research?
The studies referenced throughout this page are listed below, with links to the original papers wherever available. You can also search the peer-reviewed literature directly through PubMed.

08 — References

Scientific transparency, as a design feature.

Every reference below still needs full bibliographic verification before this site leaves prototype. None should be read as a confirmed citation yet.

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  • Aoki, K., Nakao, A., Adachi, T., Matsui, Y., Miyakawa, S. (2012). "Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes." Medical Gas Research, 2, 12. doi:10.1186/2045-9912-2-12. PMID: 22520831.Verify full citation
  • Zhou, K., Yuan, C., Shang, Z., Jiao, W., Wang, Y. (2024). "Effects of 8 days intake of hydrogen-rich water on muscular endurance performance and fatigue recovery during resistance training." Frontiers in Physiology, 15, 1458882. doi:10.3389/fphys.2024.1458882. PMID: 39434721.Verify full citation
  • Koyama, K., Dobashi, S., Takeuchi, K. (2020). "Hydrogen-rich water suppresses the reduction in blood total antioxidant capacity induced by 3 consecutive days of severe exercise in physically active males." Medical Gas Research, 10(1), 21. doi:10.4103/2045-9912.279979. PMID: 32189665.Verify full citation
  • Beddoes, T. (1793). Correspondence proposing hydrogen inhalation as a therapy, addressed to Erasmus Darwin.Verify source
  • Cavallo, T. (1798). Reported observations on hydrogen inhalation.Verify source
  • Powers, S.K., Duarte, J., Kavazis, A.N., Talbert, E.E. (2010). "Reactive oxygen species are signalling molecules for skeletal muscle adaptation." Experimental Physiology, 95(1), 1–9. doi:10.1113/expphysiol.2009.050526.Verify full citation
  • Powers, S.K. et al. (2020). "Exercise-induced oxidative stress: Friend or foe?" Journal of Sport and Health Science. PMID: 32380253.Verify full citation
  • Gomez-Cabrera, M.C. et al. (2021). "Redox-related biomarkers in physical exercise." Redox Biology. doi:10.1016/j.redox.2021.101956.Verify full citation
  • Peake, J.M. et al. (2017). "Muscle damage and inflammation during recovery from exercise." Journal of Applied Physiology. PMID: 28035017.Verify full citation
  • Margaritelis, N.V. et al. (2020). "Redox basis of exercise physiology." Redox Biology, 35, 101499.Verify full citation
  • Powers, S.K. et al. (2024). "Reactive oxygen species promote endurance exercise-induced adaptations in skeletal muscles."Citation required
  • Sies, H. (2021). "Oxidative eustress: On constant alert for redox homeostasis." Redox Biology, 41, 101867. doi:10.1016/j.redox.2021.101867.Verify full citation
  • Kruk, J. et al. (2019). "Oxidative stress in biological systems and its relation with pathophysiological functions: the effect of physical activity on cellular redox homeostasis." Free Radical Research, 53(5), 497–521.Verify full citation
  • LeBaron, T.W., Sharpe, R., Ohno, K. (2022). "Electrolyzed-Reduced Water: Review I. Molecular Hydrogen Is the Exclusive Agent Responsible for the Therapeutic Effects." International Journal of Molecular Sciences, 23(23), 14750. doi:10.3390/ijms232314750.Verify full citation
  • Ohta, S. (2015). "Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications." Methods in Enzymology, 555, 289–317. doi:10.1016/bs.mie.2014.11.038.Verify full citation
  • Penders, J. et al. (2014). "ONOOH does not react with H₂: Potential beneficial effects of H₂ as an antioxidant by selective reaction with hydroxyl radicals and peroxynitrite." Free Radical Biology & Medicine. doi:10.1016/j.freeradbiomed.2014.07.025.Verify full citation
  • Radyuk, S.N. (2021). "Mechanisms Underlying the Biological Effects of Molecular Hydrogen." Current Pharmaceutical Design, 27(5), 626–735. doi:10.2174/1381612826666201211112846. PMID: 33308112.Verify full citation
  • "Investigation of the Gas Permeation Properties Using the Volumetric Analysis Technique for Polyethylene Materials Enriched with Pure Gases under High Pressure: H₂, He, N₂, O₂ and Ar." (2023). Polymers, 15(19), 4019.Verify full citation
  • Shimouchi, A., Nose, K., Shirai, M., Kondo, T. (2012). "Estimation of molecular hydrogen consumption in the human whole body after the ingestion of hydrogen-rich water." Advances in Experimental Medicine and Biology, 737, 245–250. doi:10.1007/978-1-4614-1566-4_36. PMID: 22259109.Verify full citation
  • Shimouchi, A., Nose, K., Yamaguchi, M., Ishiguro, H., Kondo, T. (2009). "Breath hydrogen produced by ingestion of commercial hydrogen water and milk." Biomarker Insights, 4, 27–32. doi:10.4137/BMI.S2209. PMID: 19652760.Verify full citation
  • Zhou, K., Shang, Z., Yuan, C., Guo, Z., Wang, Y., Bao, D., Zhou, J. (2024). "Can molecular hydrogen supplementation enhance physical performance in healthy adults? A systematic review and meta-analysis." Frontiers in Nutrition, 11, 1387657. doi:10.3389/fnut.2024.1387657. PMID: 38903627.Verify full citation
  • Ogannisyan, M., Slivin, A., LeBaron, T.W., Tarnava, A., Karmazin, V., Bazanovich, S., Dolgachev, V., Vychik, A., Strizhkov, A., Parastaev, S. (2025). "Hydrogen-Rich Water Decreases Muscle Damage and Improves Power Endurance in Elite Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial." Journal of Lifestyle Medicine, 15(1), 8–17. doi:10.15280/jlm.2025.15.1.8. PMID: 40376695.Verify full citation
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  • Zhang, X., Xie, F., Ma, S., Ma, C., Jiang, X., Yi, Y., Song, Y., Liu, M., Zhao, P., Ma, X. (2023). "Mitochondria: one of the vital hubs for molecular hydrogen's biological functions." Frontiers in Cell and Developmental Biology, 11, 1283820. doi:10.3389/fcell.2023.1283820. PMID: 38020926.Verify full citation
  • Nishimaki, K., Asada, T., Ohsawa, I. et al. (2018). "Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment." Current Alzheimer Research, 15(5), 482–492. doi:10.2174/1567205014666171106145017. PMID: 29110615.Verify full citation
  • Zanini, D., Todorovic, N., Korovljev, D., Stajer, V., Ostojic, J., Purac, J., Kojic, D., Vukasinovic, E., Djordjievski, S., Sopic, M., Guzonjic, A., Ninic, A., Erceg, S., Ostojic, S.M. (2021). "The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: A randomized controlled pilot trial." Experimental Gerontology, 155, 111574. doi:10.1016/j.exger.2021.111574. PMID: 34601077.Verify full citation
  • Shinada, T., Kokubun, K., Takano, Y., Iki, H., Kobayashi, K., Hamasaki, T., Taki, Y. (2024). "Effects of natural reduced water on cognitive functions in older adults: A RCT study." Heliyon, 10(19), e38505. doi:10.1016/j.heliyon.2024.e38505. PMID: 39397929.Verify full citation
  • Zhou, K., Liu, M., Wang, Y., Liu, H., Manor, B., Bao, D., Zhang, L., Zhou, J. (2023). "Effects of molecular hydrogen supplementation on fatigue and aerobic capacity in healthy adults: A systematic review and meta-analysis." Frontiers in Nutrition, 10, 1094767. doi:10.3389/fnut.2023.1094767. PMID: 36819697.Verify full citation
  • Sládečková, B., Botek, M., Krejčí, J., Valenta, M., McKune, A., Neuls, F., Klimešová, I. (2024). "Hydrogen-rich water supplementation promotes muscle recovery after two strenuous training sessions performed on the same day in elite fin swimmers: randomized, double-blind, placebo-controlled, crossover trial." Frontiers in Physiology, 15, 1321160. doi:10.3389/fphys.2024.1321160. PMID: 38681143.Verify full citation
  • Li, Y., Bing, R., Liu, M., Shang, Z., Huang, Y., Zhou, K., Bao, D., Zhou, J. (2024). "Can molecular hydrogen supplementation reduce exercise-induced oxidative stress in healthy adults? A systematic review and meta-analysis." Frontiers in Nutrition, 11, 1328705. doi:10.3389/fnut.2024.1328705. PMID: 38590828.Verify full citation
  • Hylemon, P.B., Harris, S.C., Ridlon, J.M. (2018). "Metabolism of hydrogen gases and bile acids in the gut microbiome." FEBS Letters, 592(12), 2070–2082. doi:10.1002/1873-3468.13064. PMID: 29683480.Verify full citation
  • Kurokawa, R., Seo, T., Sato, B., Hirano, S., Sato, F. (2015). "Convenient methods for ingestion of molecular hydrogen: drinking, injection, and inhalation." Medical Gas Research, 5, 13. doi:10.1186/s13618-015-0034-2. PMID: 26504515.Verify full citation

Understand the science.
Then decide what it means for your performance.

Explore the Research

This site is provided for educational purposes only and does not constitute medical advice. It does not diagnose, treat, prevent or cure any condition. Research findings referenced or summarised here — including those still marked for citation — do not guarantee any individual outcome. Speak to a qualified healthcare professional before changing your training, recovery or health practices.

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